Research Articles and Reviews
Dovek L, Marrero K, Zagha E, Santhakumar V. Cellular and circuit features distinguish dentate gyrus semilunar granule cells and granule cells activated during contextual memory formation. bioRxiv. 2024
Marrero K, Aruljothi K, Delgadillo C, Kabbara S, Swatch L, Zagha E. Goal-Directed Learning is Multidimensional and Accompanied by Diverse and Widespread Changes in Neocortical Signaling. Cerebral Cortex. 2024, 34 (8):bhae328
Zhang Z, Zagha, E. Motor Cortex Gates Distractor Stimulus Encoding in Sensory Cortex. Nature Communications. 2023, 14 (1), 2097
Zareian B, Lam A, Zhang Z, Zagha, E. Dorsolateral Striatal is a Bottleneck for Responding to Task-Relevant Stimuli in a Learned Whisker Detection Task in Mice. Journal of Neuroscience. 2023, 43 (12), 2126-2139
Zagha E, Erlich JC, Lee S, Lur G, O’Connor DH, Steinmetz NA, Stringer C, Yang H. The Importance of
Accounting for Movement When Relating Neuronal Activity to Sensory and Cognitive Processes. Journal of Neuroscience 2022 Feb 23;42(8):1375-1382
J McBurney-Lin, G Vargova, M Garad, E Zagha, H Yang. The locus coeruleus mediates behavioral flexibility. Cell Reports. 2022, 41 (4)
Marrero K, Aruljothi K, Zareian B, Gao C, Zhang Z, Zagha E Global, Low Amplitude Cortical State Predicts Response Outcomes in a Selective Detection Task. Cerebral Cortex. 2022 Apr 20;32(9):2037-2053
Zareian B, Zhang Z, Zagha E Cortical Localization of the Sensory-Motor Transformation in a Whisker Detection Task in Mice. eNeuro 2021, Feb 1;8(1):ENEURO.0004-21.2021
Aruljothi K, Marrero K, Zhang Z, Zareian B, Zagha E. Functional Localization of an Attenuating Filter within Cortex for a Selective Detection Task in Mice. Journal of Neuroscience. 2020 Jul 8;40(28):5443-5454
Zagha E. Shaping the Cortical Landscape: Functions and Mechanisms of Top-Down Cortical Feedback Pathways. Front Syst Neurosci. 2020 Jun 10;14:33
Salkoff DB, Zagha E, McCarthy E, McCormick DA. Movement and Performance Explain Widespread Cortical Activity in a Visual Detection Task. Cerebral Cortex. 2020 Jan 10;30(1):421-437
Batista-Brito R, Zagha E, Ratliff JM, Vinck M. Modulation of cortical circuits by top-down processing and arousal state in health and disease. Curr Opin Neurobiol. 2018 Oct;52:172-181
Zagha E, Murray JD, McCormick D. Simulating Cortical Feedback Modulation as Changes in Excitation and Inhibition in a Cortical Circuit Model. eNeuro. 2016 Aug 31:3(4)
Ferrante M, Tahvildari B, Duque A, Hadzipasic M, Salkoff D, Zagha EW, Hasselmo ME, McCormick DA. Distinct Functional Groups Emerge from the Intrinsic Properties of Molecularly Identified Entorhinal Interneurons and Principal Cells. Cerebral Cortex. 2016 Jun 6
Zagha E, Ge X, McCormick D. Competing neural ensembles in motor cortex gate goal-directed motor output. Neuron. 2015 Nov 4:88(3):565–577
McGinley M, Vinck M, Reimer J, Batista-Brito R, Zagha E, Cadwell C, Tolias A, Cardin J, McCormick D. Waking State: Rapid Variations Modulate Neural and Behavioral Responses. Neuron. 2015 Sept 23;87(6): 1143–1161
Salkoff D, Zagha E, Yuzgec O, McCormick, D. Synaptic mechanisms of tight spike synchrony at gamma frequency in cerebral cortex. Journal of Neuroscience. 2015 Jul 5;35(28):10236-51
Zagha E, McCormick D. Neural control of brain state. Current Opinion in Neurobiology. 2014 Oct; 10(29):178-186
Amarillo Y, Zagha E, Mato G, Rudy B, Nadal MS. The interplay of seven subthreshold conductances controls the resting membrane potential and the oscillatory behavior of thalamocortical neurons. Journal of Neurophysiology. 2014 Jul 15;112(2):393-410
Zagha E, Casale A, Sachdev R, McGinley M, McCormick D. Motor cortex feedback influences sensory processing by modulating network state. Neuron. 2013 Aug 7;79(3):567-78
^^ Previewed in Harris KD. Top-Down Control of Cortical State. Neuron, same issue.
Lee S, Hjerling-Leffler J, Zagha E, Fishell G, Rudy B. The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors. Journal of Neuroscience. 2010 Dec 5;30(50):16796-808
Zagha E, Manita S, Ross WN, Rudy B. Dendritic Kv3.3 channels in Purkinje cells regulate generation and spatial dynamics of dendritic Ca2+ spikes. Journal of Neurophysiology. 2010 Jun;103(6):3516-25
Rudy B, Maffie J, Amarillo Y, Clark B, Goldberg EM, Jeong HY, Kruglikov I, Kwon E, Nadal M, Zagha E. Voltage Gated Potassium Channels: Structure and Function of Kv1 to Kv9 Subfamilies. In: Squire LR, editor. Encyclopedia of Neuroscience. Volume 10. Oxford: Academic Press (2009) 397-425.
Goldberg EM, Clark BD, Zagha E, Nahmani M, Erisir A, Rudy B. K+ channels at the axon initial segment dampen near-threshold excitability of neocortical fast-spiking GABAergic interneurons. Neuron. 2008 May; 58(3): 387-400
Zagha E, Lang EJ, Rudy B. Kv3.3 channels at the Purkinje cell soma are necessary for generation of the classical complex spike waveform. Journal of Neuroscience. 2008 Feb; 28(6): 1291-1300
Makani S, Zagha E. Out of the cleft: the source and target of extra-synaptic glutamate in the CA1 region of the hippocampus. Journal of Physiology. 2007 Jul; 582(2): 479-480
Chang SY*, Zagha E*, Kwon ES, Ozaita A, Bobik M, Martone ME, Ellisman MH, Heintz N, Rudy B. Distribution of Kv3.3 potassium channel subunits in distinct neuronal populations of mouse brain. Journal of Comparative Neurology. 2007 Jun; 502(6): 953-972. (*co-first author)
Zagha E, Ozaita A, Chang SY, Nadal MS, Lin U, Saganich MJ, McCormack T, Akinsanya KO, Qi SY, Rudy B. DPP10 modulates Kv4-mediated A-type potassium channels. Journal of Biological Chemistry. 2005 May; 280(19): 18853-18861
Sommer MH, Zagha E, Serrano OK, Ku CC, Zerboni L, Baiker A, Santos R, Spengler M, Lynch J, Grose C, Ruyechan W, Hay J, Arvin AM. Mutational analysis of the repeated open reading frames, ORFs 63 and 70 and ORFs 64 and 69, of varicella-zoster virus. Journal of Virology. 2001 Sep; 75(17): 8224-8239
Marrero K, Aruljothi K, Delgadillo C, Kabbara S, Swatch L, Zagha E. Goal-Directed Learning is Multidimensional and Accompanied by Diverse and Widespread Changes in Neocortical Signaling. Cerebral Cortex. 2024, 34 (8):bhae328
Zhang Z, Zagha, E. Motor Cortex Gates Distractor Stimulus Encoding in Sensory Cortex. Nature Communications. 2023, 14 (1), 2097
Zareian B, Lam A, Zhang Z, Zagha, E. Dorsolateral Striatal is a Bottleneck for Responding to Task-Relevant Stimuli in a Learned Whisker Detection Task in Mice. Journal of Neuroscience. 2023, 43 (12), 2126-2139
Zagha E, Erlich JC, Lee S, Lur G, O’Connor DH, Steinmetz NA, Stringer C, Yang H. The Importance of
Accounting for Movement When Relating Neuronal Activity to Sensory and Cognitive Processes. Journal of Neuroscience 2022 Feb 23;42(8):1375-1382
J McBurney-Lin, G Vargova, M Garad, E Zagha, H Yang. The locus coeruleus mediates behavioral flexibility. Cell Reports. 2022, 41 (4)
Marrero K, Aruljothi K, Zareian B, Gao C, Zhang Z, Zagha E Global, Low Amplitude Cortical State Predicts Response Outcomes in a Selective Detection Task. Cerebral Cortex. 2022 Apr 20;32(9):2037-2053
Zareian B, Zhang Z, Zagha E Cortical Localization of the Sensory-Motor Transformation in a Whisker Detection Task in Mice. eNeuro 2021, Feb 1;8(1):ENEURO.0004-21.2021
Aruljothi K, Marrero K, Zhang Z, Zareian B, Zagha E. Functional Localization of an Attenuating Filter within Cortex for a Selective Detection Task in Mice. Journal of Neuroscience. 2020 Jul 8;40(28):5443-5454
Zagha E. Shaping the Cortical Landscape: Functions and Mechanisms of Top-Down Cortical Feedback Pathways. Front Syst Neurosci. 2020 Jun 10;14:33
Salkoff DB, Zagha E, McCarthy E, McCormick DA. Movement and Performance Explain Widespread Cortical Activity in a Visual Detection Task. Cerebral Cortex. 2020 Jan 10;30(1):421-437
Batista-Brito R, Zagha E, Ratliff JM, Vinck M. Modulation of cortical circuits by top-down processing and arousal state in health and disease. Curr Opin Neurobiol. 2018 Oct;52:172-181
Zagha E, Murray JD, McCormick D. Simulating Cortical Feedback Modulation as Changes in Excitation and Inhibition in a Cortical Circuit Model. eNeuro. 2016 Aug 31:3(4)
Ferrante M, Tahvildari B, Duque A, Hadzipasic M, Salkoff D, Zagha EW, Hasselmo ME, McCormick DA. Distinct Functional Groups Emerge from the Intrinsic Properties of Molecularly Identified Entorhinal Interneurons and Principal Cells. Cerebral Cortex. 2016 Jun 6
Zagha E, Ge X, McCormick D. Competing neural ensembles in motor cortex gate goal-directed motor output. Neuron. 2015 Nov 4:88(3):565–577
McGinley M, Vinck M, Reimer J, Batista-Brito R, Zagha E, Cadwell C, Tolias A, Cardin J, McCormick D. Waking State: Rapid Variations Modulate Neural and Behavioral Responses. Neuron. 2015 Sept 23;87(6): 1143–1161
Salkoff D, Zagha E, Yuzgec O, McCormick, D. Synaptic mechanisms of tight spike synchrony at gamma frequency in cerebral cortex. Journal of Neuroscience. 2015 Jul 5;35(28):10236-51
Zagha E, McCormick D. Neural control of brain state. Current Opinion in Neurobiology. 2014 Oct; 10(29):178-186
Amarillo Y, Zagha E, Mato G, Rudy B, Nadal MS. The interplay of seven subthreshold conductances controls the resting membrane potential and the oscillatory behavior of thalamocortical neurons. Journal of Neurophysiology. 2014 Jul 15;112(2):393-410
Zagha E, Casale A, Sachdev R, McGinley M, McCormick D. Motor cortex feedback influences sensory processing by modulating network state. Neuron. 2013 Aug 7;79(3):567-78
^^ Previewed in Harris KD. Top-Down Control of Cortical State. Neuron, same issue.
Lee S, Hjerling-Leffler J, Zagha E, Fishell G, Rudy B. The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors. Journal of Neuroscience. 2010 Dec 5;30(50):16796-808
Zagha E, Manita S, Ross WN, Rudy B. Dendritic Kv3.3 channels in Purkinje cells regulate generation and spatial dynamics of dendritic Ca2+ spikes. Journal of Neurophysiology. 2010 Jun;103(6):3516-25
Rudy B, Maffie J, Amarillo Y, Clark B, Goldberg EM, Jeong HY, Kruglikov I, Kwon E, Nadal M, Zagha E. Voltage Gated Potassium Channels: Structure and Function of Kv1 to Kv9 Subfamilies. In: Squire LR, editor. Encyclopedia of Neuroscience. Volume 10. Oxford: Academic Press (2009) 397-425.
Goldberg EM, Clark BD, Zagha E, Nahmani M, Erisir A, Rudy B. K+ channels at the axon initial segment dampen near-threshold excitability of neocortical fast-spiking GABAergic interneurons. Neuron. 2008 May; 58(3): 387-400
Zagha E, Lang EJ, Rudy B. Kv3.3 channels at the Purkinje cell soma are necessary for generation of the classical complex spike waveform. Journal of Neuroscience. 2008 Feb; 28(6): 1291-1300
Makani S, Zagha E. Out of the cleft: the source and target of extra-synaptic glutamate in the CA1 region of the hippocampus. Journal of Physiology. 2007 Jul; 582(2): 479-480
Chang SY*, Zagha E*, Kwon ES, Ozaita A, Bobik M, Martone ME, Ellisman MH, Heintz N, Rudy B. Distribution of Kv3.3 potassium channel subunits in distinct neuronal populations of mouse brain. Journal of Comparative Neurology. 2007 Jun; 502(6): 953-972. (*co-first author)
Zagha E, Ozaita A, Chang SY, Nadal MS, Lin U, Saganich MJ, McCormack T, Akinsanya KO, Qi SY, Rudy B. DPP10 modulates Kv4-mediated A-type potassium channels. Journal of Biological Chemistry. 2005 May; 280(19): 18853-18861
Sommer MH, Zagha E, Serrano OK, Ku CC, Zerboni L, Baiker A, Santos R, Spengler M, Lynch J, Grose C, Ruyechan W, Hay J, Arvin AM. Mutational analysis of the repeated open reading frames, ORFs 63 and 70 and ORFs 64 and 69, of varicella-zoster virus. Journal of Virology. 2001 Sep; 75(17): 8224-8239